Research Week 2024

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https://hdl.handle.net/20.500.14446/344092

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Relationship between restricted ankle dorsiflexion and knee kinematic changes during static and dynamic movements in physically active adults: A critically appraised topic
(Oklahoma State University Center for Health Sciences, 2024-02-16) Monnier, Jessica; Komlodi, Tatum B.; O’Brien, Matthew S.
Clinical scenario: Knee injuries are prevalent among athletes across a multitude of sports whether it be females or males. Restricted joint motion above or below the knee joint can contribute to the incidence of these injuries during static or dynamic movements.
Empowering students through a faculty-student mentorship program
(Oklahoma State University Center for Health Sciences, 2024-02-16) Davidson, Brenda J.
Introduction/Objective: Diversity and cultural competence in osteopathic medical education are critical to both student success and healthcare delivery in rural, marginalized, and underserved communities. The study assesses an intervention designed to develop a diverse and culturally informed workforce through a faculty-student mentorship program. A 40-hour faculty workshop was administered at a leading college of osteopathic medicine. Seventeen presentations delivered 40 hours of content to ten faculty participants over four months. The primary aim of this research is to evaluate the effectiveness of a Faculty Mentorship Program in enhancing academic success and diversity among students in osteopathic medical education. The secondary objective is to assess how this mentorship program influenced participating students' intent to practice in rural and medically underserved areas. Honoring the mission of our College of Osteopathic Medicine, we hypothesize that program participants demonstrate greater cultural awareness and interest in working in rural and underserved communities.
Exploring affordable solutions for orthopedic medications: A comparative study of Mark Cuban Cost Plus drug company (MCCPDC) and medicare
(Oklahoma State University Center for Health Sciences, 2024-02-16) Young, Alec; Jelinek, Trevon; Smith, Tim; Elfar, Annes; Rashid, Matthew; Duncan, Jacob; Checketts, Jake X.; Anderson, J. Michael; Vassar, Matt
Background: Healthcare spending on medications has continued to rise over the years, presenting a dilemma with affordable medications, notably in the field of orthopedics. To combat this issue, the Mark Cuban Cost Plus Drug Company (MCCPDC) platform has been established as an alternative to lower the financial burden placed on patients. The goal of this study is to assess the differences between MCCPDC and Medicare Part D orthopedic medication pricing.
Survey of the perceptions, knowledge, and use of core outcome sets in knee and hip osteoarthritis trials: A cross-sectional study
(Oklahoma State University Center for Health Sciences, 2024-02-16) Woodson, Calon; Lang, Peter; Molina, Daniel; Nguyen, Khanh; Jelinek, Trevon; Young, Alec; Hall, R. Hunter; Chaudhry, Asaad; Cox, Katherine; Hughes, Griffin; Vassar, Matt
Background: Osteoarthritis (OA) of the knee and hip is a prevalent and financially burdening cause of disability globally. Thus, significant effort towards developing effective clinical practices to manage this disease is warranted. Clinical trials play an integral role in guiding clinical practices, and thus an increase in the number of trials performed. With this increasing number of trials, it is imperative to decrease outcome reporting heterogeneity. Core outcome sets (COS) are used to standardize clinical trial outcomes which serves to increase the comparability of clinical trial results and reduce reporting bias. By gathering our data from clinical researchers themselves, our goal is to gain an understanding into the decision-making behind outcomes used and assess the researchers’ perspectives on the current OA COS.
Comorbidities among women presenting to the ED with OB/GYN complaints
(Oklahoma State University Center for Health Sciences, 2024-02-16) Cosby, Caitlin; Dawson, Charlee; Tewari, Shannon; Hartwell, Micah
Background: The management of obstetric and gynecological emergencies are focused on the conservation of fertility and sexual function. Common OBGYN emergencies can cause pregnancy complications in the present or future and should be taken into consideration in all women presenting to the emergency department with related complaints. Common comorbidities such as hypertension, diabetes and more can precede OBGYN complications that subsequently can lead to pregnancy complications. Our primary objective was to use the National Hospital Ambulatory Medical Care Survey (NHAMCS) to assess the diagnostics and comorbidities among women who utilize the ED for obstetric and gynecologic care. Secondary objectives are to compare demographics and comorbidities among women who are insured versus uninsured, by region, and urbanicity.
Clinical perspective on core outcome sets in chronic kidney disease trials: A web-based survey study
(Oklahoma State University Center for Health Sciences, 2024-02-16) Wood, Ethan; Smith, Harrison; Corwin, Logan P.; Marchbanks, Jeanie; Hagood, Alex; Tran, Andrew V.; Rashid, Matthew; Ernst, Zachary; Chaudhry, Asaad; Cox, Katherine; Hughes, Griffin; Vassar, Matt
Introduction: Clinical trials are crucial for medical advancements, with Core Outcome Sets (COS) proving to be an important tool for reducing variability and standardizing outcome measurements. Given the high prevalence and severe complications of Chronic Kidney Disease (CKD), utilizing COS in CKD research can lead to more effective preventative and therapeutic measures. This study aims to understand the adoption of COS within the CKD research community, identify potential barriers and improvements, and provide insights for future strategies to maximize the quality and comparability of CKD trial outcomes.
Blue light therapy in those with concussions to improve sleep quality and or sleep disturbances
(Oklahoma State University Center for Health Sciences, 2024-02-16) Wells, Bradlee; Meche, Audrey; Warren, Aric
Background: Utilizing data from the 2017 national Youth Risk Behavior Survey, the Center for Disease Control analyzed the prevalence of concussions in high school aged students and estimated that approximately 15% of students (2.5 million) reported having at least one concussion during the study period. Concussions are a form of traumatic brain injury (TBI) and can cause problems such as headaches, dizziness, dazed or confusion, difficulty remembering or concentrating, vomiting, blurred vision, but one of the most common complications that can occur from concussions are sleep disturbances/disorders. About 90% of those who have a TBI reported some type of sleep disturbance that include insomnia, frequent wakefulness after onset sleep, general sense of poor sleep quality, disordered breathing, fatigue, increased need for sleep, and or daytime sleepiness that may possibly interfere with daily living activities. Previous evidence suggests that daily blue wavelength light therapy (BLT) may be effective at reducing fatigue and improving sleep in patients recovering from mild TBI. Therefore, the clinical question of this critical appraisal is: does BLT help improve overall sleep quality and or sleep disturbances in those with concussions?
Influence of publications on the management of appendicitis
(Oklahoma State University Center for Health Sciences, 2024-02-16) Walker, John; Marlar, Riley; Eghbali, Niloufar; Lippard, Justin; Han, Zheng; Delen, Dursun; Paiva, William; Ghassemi, Mohammad M.; Vassar, Matt
Introduction: This article examines the influence of scientific knowledge dissemination on medical practices, specifically the shift in appendicitis management from surgical to non-operative approaches. By analyzing CPT codes and publication data from PubMed, we establish a positive relationship between surgery ratio and average citations per publication, indicating higher adoption of non-operative management with increased citations. This study contributes to understanding how knowledge dissemination impacts patient care and drives changes in medical practices. Understanding the influence of scientific knowledge dissemination on medical practices can pave the way for evidence-based advancements in healthcare, potentially leading to improved patient care and outcomes. Recently, there has been a significant shift in the management of appendicitis from surgical treatment to non-operative approaches using antibiotics. Our hypothesis posits that this shift is driven by scientific discoveries documented in published literature. This paper seeks to uncover the influence of scientific literature on clinical decisions and its impact on patient care, contributing to evidence-based healthcare advancements.
LEAN healthcare: Evaluation of the discharge process at mid-sized hospital
(Oklahoma State University Center for Health Sciences, 2024-02-16) Vaughn, Hannah; Donaldson, Vanessa; Ceesay, Mariama; Crowell, Emily; Do, Victor; Handa, Kylie; Haxel, Victoria; Tucker, Myles
Introduction/Objectives: A team of 8 osteopathic medical students were tasked with learning and implementing the LEAN process. LEAN is a philosophy of process improvement through creation of standard workflow and minimization of waste. Oklahoma State University Center for Health Systems Innovation in partnership with Oklahoma State University Medical Center tasked the team with identifying inefficiencies embedded within the Discharge Process specifically, patients being discharged from inpatient units. This research discusses the teams findings and recommendations provided to hospital leadership.
Rates and disparities in emergency department treatment of alcohol use disorder
(Oklahoma State University Center for Health Sciences, 2024-02-16) Walker, John; Marlar, Riley; Thompson, Mackenzee; Han, Zheng; Collins, Hunter; Delen, Dursun; Vassar, Matt
Background: Alcohol Use Disorder (AUD) remains the third leading cause of preventable death in the United States. Yet, AUD continues to be undertreated. Medication-assisted treatment (MAT) prescribed in the Emergency Department (ED) has demonstrated efficacy in treating other substance use disorders, prompting recommendations for treatment of AUD as well. Our objective is to identify the prevalence of MAT initiation for AUD during ED visits, as well as demographics and concurrent diagnoses that influence treatment initiation.
Educate Exercise Empower Why walk with a doc? Initial findings suggest the importance of social connection
(Oklahoma State University Center for Health Sciences, 2024-02-16) VanNortwick, Stephanie M.; Haight, Macy; Sweat, Carly; Phillips, Jarrett; Bray, Natasha
Background: It is widely known that regular physical activity is important to overall health and well-being. In Cherokee County access to exercise opportunities is not widely available compared to the State of Oklahoma and nationwide. To combat lack of access and provide health education, a Tahlequah chapter of Walk with a Doc (WWAD) began in July 2023 in partnership with Oklahoma State College of Osteopathic Medicine at the Cherokee Nation, Northeastern Oklahoma Community Health Centers, and Cherokee County Active Living and Transportation Committee. WWAD is an international nonprofit organization founded in 2005 by board-certified cardiologist Dr. David Sabgir, MD. Dr. Sabgir envisioned a program that provides communities with recurring opportunities to engage in physical activity, while creating an inclusive environment for conversation with local medical providers. Our objective is to investigate the reason individuals chose to participate in the program and initial impacts to inform future health program design.
Exploring clinical trialists’ perspectives on core outcome sets for immune thrombocytopenic purpura (ITP) trials: A web-based survey study
(Oklahoma State University Center for Health Sciences, 2024-02-16) Tytanic, Madison; Rowsey, Kaylyn; Swami, Vinay; Chaudhry, Mahad; Stadler, John K.; Khan, Adam; Chaudhry, Asaad; Cox, Katherine; Ernst, Zachary; Hughes, Griffin; Vassar, Matt
Introduction: Immune Thrombocytopenic Purpura (ITP) is a complex autoimmune disorder associated with a low platelet count, and elevated bleeding risk. Conducting clinical trials in ITP is vital for comprehending the disease and improving patient outcomes. However, diverse outcome measures across trials impede result comparison, necessitating the use of Core Outcome Sets (COS). COS are specific trial outcomes for uniform measurement and reporting, aiming to enhance research quality, evidence synthesis, and patient-centered outcomes. Despite potential benefits, COS adoption in the ITP clinical trial community remains inconsistent. This cross-sectional, web-based survey investigates clinical trialists' perceptions, knowledge, and usage patterns of COS in ITP research. Our objective is to obtain insight on the awareness, integration, barriers, and recommendations for ITP COS. This study's insights aim to inform strategies for enhancing COS adoption, advancing standardization in ITP trials, and optimizing therapeutic intervention evidence.
Medicare savings for seizure drugs by adopting the Mark Cuban Cost Plus drug company model
(Oklahoma State University Center for Health Sciences, 2024-02-16) Smith, Tim; Young, Alec; Duncan, Jacob; Rashid, Matthew; O’Brien, Cameron; Magee, Trevor; Fitzgerald, Kyle; Vassar, Matt
Background: Epilepsy is often a lifelong diagnosis, requiring pharmacologic management in most cases. Despite the chronicity of this disorder and management, there has been a rise in medication cost over the years. To address this issue, Mark Cuban Cost Plus Drug Company (MCCPDC) has come out as a more affordable option to obtain patients’ prescriptions. Focusing on epileptic medication, this study examines the potential cost saving benefit of MCCPDC compared to Medicare Part D plans.
Rates of adolescent suicidal ideation in self-reported AI/AN race: A cross sectional analysis of the Youth Risk Behavior Surveillance System
(Oklahoma State University Center for Health Sciences, 2024-02-16) Smith, Parker; Noblin, KayLeigh; Hendrix-Dicken, Amy; Dunlap, Michael; Hartwell, Micah
Background: Suicide is among the leading causes of death among children in the United States, ranking second among ages 10-14 and third among those 15-24. Non-Hispanic American Indian/Alaska Native (AI/AN) individuals are disproportionately impacted by suicide with a reported 28.1 out of 100,000 individuals dying from suicide. In an examination of suicidal ideation and suicide attempts among adolescent students aged 12-19 in the Minnesota Student Survey, individuals reported as AI/AN demonstrate elevated rates compared to other ethnic groups.1 While current statistics indicate that the suicide rate is highest among non-Hispanic AI/AN, actual rates of suicide and suicidal ideation may vary due to the number of AI/AN individuals who are classified as multiracial. Thus, our primary objective was to compare the rates of suicidal ideation among adolescents using the calculated raceeth variable in the Youth Risk Behavior Surveillance System (YRBSS) to self-reported ethnoracial identity.
Association between ACEs and the prevalence of specific negative childhood behaviors
(Oklahoma State University Center for Health Sciences, 2024-02-16) Stone, Tanner; Monahan, Zach; Hogan, Abby; Hartwell, Micah
Background: Adverse childhood experiences -stressful or traumatic events that occur to children during their development- are frequently associated with adult substance use, injury, violence, and a lower life expectancy, but also have been shown to have an immediate impact on negative behaviors during childhood. Insight into the association between ACEs and the presence of specific negative behaviors within conduct disorder diagnostic criteria has been understudied. Thus, our primary objective was to investigate the association between ACE scores and various negative childhood behaviors.
Computed tomography visualization of wormian bones in the pen-tailed tree shrew (Ptilocercus lowii)
(Oklahoma State University Center for Health Sciences, 2024-02-16) Skelton, Rozalen Doolen; Marilao, Lianna M.; Barta, Daniel E.
Wormian bones are variably ossifying bones within the sutures of skulls. While widespread among mammals, they do not occur in every specimen of species that are known to form Wormian bones. While the exact reason(s) for why these bones form is unknown, it has been hypothesized that they may form due to prolonged cranial stress. Wormian bones in primates have been studied for over a century, but to our knowledge, they have not yet been reported from Ptilocercus lowii (Pen-tailed tree shrew), a member of Scandentia, a mammalian order sometimes recovered as an outgroup to Primatomorpha, the group that includes primates. We focused on two main questions: 1) How does the location and morphology of Wormian bones vary within P. lowii? and 2) Are the locations of the Wormian bones in P. lowii the same as in primates?
Exploring data sharing practices in ophthalmology journals: A cross-sectional analysis
(Oklahoma State University Center for Health Sciences, 2024-02-16) Chaudhry, Mahad; Bratten, Chance; Oldham, Eli; Vassar, Matt
Background: Open data practices in medical research not only uphold the principles of reproducibility and integrity in scientific endeavors but also pave the way for collaborative advances by allowing researchers to build upon each other's findings. Despite the International Committee of Medical Journal Editors (ICMJE) making data sharing mandatory for clinical trials since 2017, barriers persist in research data sharing. Even decade-old ophthalmological data from the US National Institutes of Health remains unreleased as of 2023. The extent of ophthalmology's adoption of data sharing remains uncertain, influenced by journal and institutional policies, clarity of statements, and dataset prevalence and accessibility. This study aims to investigate the current state of data sharing in ophthalmology, identifying strengths, barriers, and improvement avenues. Understanding these practices is pivotal, not just for the sake of transparency, but also for ensuring the rapid advancement of ophthalmology as a discipline.
Sociodemographic disparities in diabetic eye disease: An analysis of the 2021 Behavioral Risk Factor Surveillance System
(Oklahoma State University Center for Health Sciences, 2024-02-16) Smith, Dawsyn; Hester, S. Mackenzee; Emmert, Ryan; Hartwell, Micah
Purpose: Among the various manifestations of diabetic eye disease, diabetic retinopathy, a leading cause of preventable blindness, is estimated to impact more than 160 million individuals by 2045. Our objective was to provide an update and investigate the rates of diabetic eye disease by race/ethnicity, sex, socioeconomic status, education, and rurality. Additionally, we aimed to address a gap in research by investigating the rates of diabetic eye disease among the transgender population.
Impact of implementation of a breastfeeding education program: Prospective evaluation of a community medical student-led program
(Oklahoma State University Center for Health Sciences, 2024-02-16) Shed, Allisyn; Johnson, Janel H.
Introduction/Objectives: Among children born in 2019, only 77% reported having ever been breastfed in Oklahoma, while the national average of that year was 83%. These reported rates expose the gap in breastfeeding in Oklahoma. Specifically, in Cherokee County within Oklahoma, that percentage is 78%. This deficit in the percentage of breastfed infants in Oklahoma is significant because breastfeeding provides an array of health benefits to both baby and mother. In babies, breast milk provides essential nutrients and natural passive immunity. Breastfeeding has also been shown to reduce the risks of asthma, obesity, and type I diabetes. It benefits the mother breastfeeding by reducing the chances of high blood pressure, type 2 diabetes, ovarian and breast cancer. While breastfeeding is the gold standard for infant nutrition, there are several barriers to breastfeeding that the mother can face that should be considered. Issues like latching, concerns for the infant's weight and growth, the limited choices of medications that the mother can use, lack of support from family or in the workplace, lack of education about breastfeeding, and cultural stigmas all contribute to if or how prolonged breastfeeding occurs.
Exploring clinical trialists' perspectives on core outcome sets for anxiety trials: A web-based survey study
(Oklahoma State University Center for Health Sciences, 2024-02-16) Sims, Seth; Varughese, Nathan; Hall, Elizabeth H.; Barks, Noah; Duncan, Jacob; Elfar, Annes; Chaudhry, Asaad; Cox, Katherine; Ernst, Zachary; Hughes, Griffin; Vassar, Matt
Importance: Without a consistent set of outcome measures in clinical trials, it is challenging to draw meaningful comparisons and make informed decisions regarding the most effective interventions for anxiety disorders. In an attempt to enhance research quality, a core outcome set (COS) for anxiety disorder was established in 2017 with the goal of improving the quality and comparability of clinical trials focused on anxiety disorders. The COS established a standard set of outcomes expected to be measured by trialists specifically when studying interventions related to anxiety disorders. Our study aimed to investigate the perception, knowledge and utilization of the core outcome sets by lead investigators in clinical trials of anxiety disorders.

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