Purdie Research Scholars

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Recent Submissions

  • Publication
    Fault hunting: Potentially increased seismic risk in southwestern Oklahoma
    (Oklahoma State University, 2024-04-25) Smith, Bryston P.
    The Wichita Mountains are composed of several intrusive rock units that are Cambrian in age (~532-530 Ma) and are proposed to have formed in a failed continental rift zone (Ham et al., 1964). The majority of the rock units in the Wichitas are granitic plutons which have been dated to the early- to mid-Cambrian period (Wall et al., 2020). Overlying these basement units is the Permian Post Oak formation which preserves evidence of Pennsylvanian mountain building. Mapped faults in the region include the Meers Fault, a known seismogenic feature which has considerable seismicity as recently as 1,200 years bp (Chase et al., 2022. Recent investigation of high-resolution digital elevation models (DEM) has led to the tentative identification of additional structural features in the area. This study aims to utilize field structural mapping and outcrop characterization to confirm the existence of these features and determine their potential contribution to seismicity in southwestern Oklahoma.
  • Publication
    Role of FMRP in regulating the tonotopic distribution of C-fos expression levels in the LSO, AVCN, and MNTB
    (Oklahoma State University, 2023-04-27) Ray, Ishani; Stringer, Collin
    Does FMRP play a role in the rapid experience dependent expression of C-fos along the tonotopic axis of LSO, AVCN and MNTB?
  • Publication
    Characterization of auditory physiology in FXS mice at critical developmental timepoints
    (Oklahoma State University, 2023-04-27) Ray, Ishani; Chawla, Amita
    Autism spectrum disorders are strongly associated with auditory hypersensitivity. Fragile X syndrome (FXS), a common monogenic cause of ASD, results from transcriptional silencing of the Fmr1 gene and reduced expression of fragile X messenger ribonucleo-protein (FMRP). FMRP directly impacts myelin proteins and various brain regions show reduced/delayed myelination in FXS, suggesting deficits seen in FXS may be caused by alterations to myelination. FXS is a neurodevelopmental disorder, therefore characterizing when during development auditory dysfunction arises in addition to understanding if these changes are myelin dependent is critical to elucidating the full etiology of FXS. Auditory brainstem response (ABR) measurements record 1-4 waves, each corresponding to part of the ascending auditory pathway; the latency of which could be directly related to myelination of auditory areas. To characterize the physiology of myelination deficits in FXS at developmental time points, ABR measurements were taken for transgenic Fmr1 mice and controls before (P8-10), during (P12-14) or after (P21-23 and adult) hearing onset in mice. This allowed us to study the developmental emergence of auditory disruptions in Fmr1 transgenic mice and identify critical windows where underlying auditory pathways are established. We hypothesize that transgenic Fmr1 mice will have increased latencies and decreased amplitudes in their ABR waves compared to the wildtype at different developmental time points. These data will aid in identifying the critical developmental windows of neural circuitry establishment in auditory sensory systems and potential myelination impairments that underly auditory dysfunction observed in patients and mice with FXS.