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Publication

New Mycobacterium avium antifolate shows synergistic effect when used in combination with dihydropteroate synthase inhibitors

Suling, W. J.
Seitz, L. E.
Reynolds, R. C.
Barrow, W. W.
Abstract
Mycobacterium avium complex (MAC) is resistant to trimethoprim, an inhibitor of bacterial dihydrofolate reductase (DHFR). A previously identified selective inhibitor of MAC DHFR, SRI-8858, was shown to have synergistic activity in combination with dapsone and sulfamethoxazole, two drugs that inhibit bacterial dihydropteroate synthase.
Date
2005-11