Loading...
Thumbnail Image
Publication

Direct Determination of Nicotine by Circular Dichroism Spectropolarimetry

Atkinson, William Marc
Abstract
Circular Dichroism (CD), a nontraditional analytical technique, is evaluated for the analysis of nicotine and its major metabolite cotinine. A comparison of the CD and uv-visible methods for the analysis of nicotine in tobacco samples exemplifies many of the advantages the CD method has over other methods of analysis. The CD spectra of nicotine and cotinine are characterized and methods for the subsequent quantitative analysis are outlined. The binding constant for a nicotine-B-cyclodextrin complex is determined -and efforts to analyze a cotinine/nicotine binary mixture are described.
Date
1983-05-01
Collections