Day, JonWeaver, Jimmie D., IIINoel, AlyssaHamilton, MatthewJesperson, DanielKeen, BrocktonHHMI Life Science Freshman Research Scholars2019-07-222019-07-222019-04-27Noel, A., Hamilton, M., Jesperson, D., Keen, B., Day, J., & Weaver, J. D. (2019, April 27). A single step polyfluoroarylation of amides. Paper presented at the HHMI Life Science Freshman Research Scholars Symposium, Stillwater, OK.https://hdl.handle.net/20.500.14446/321026Per- and polyfluoroarenes are important synthetic chemistry targets because they are active components in many pharmaceuticals, agrichemicals, and industrial manufacturing products. Many of the current methods of synthesizing these fluoroarenes involves selectively adding fluorines one at a time. These procedures are rudimentary and often demand long and harsh reaction conditions and often result in poor yields. Novel substrates can be reached, however, through selective hydrodefluorination or functionalization, i.e. fluorine sculpting. This research compliments recently developed chemistry which synthesizes starting material fluoroarenes in two steps by shortening the synthesis by 50%. This chemistry utilizes nucleophilic aromatic substitution to synthesize per- and poly-fluoroaryl amides in a single step under mild reaction conditions which can then be utilized for fluorine sculpting.application/pdfIn the Oklahoma State University Library's institutional repository this paper is made available through the open access principles and the terms of agreement/consent between the author(s) and the publisher. The permission policy on the use, reproduction or distribution of the article falls under fair use for educational, scholarship, and research purposes. Contact Digital Resources and Discovery Services at lib-dls@okstate.edu or 405-744-9161 for further information.Research reportpolyfluoroarylationamidessnarorganofluorinesfluorine