Jiang, ZhenPiao, DaqingXu, GuanRitchey, Jerry W.Reed Holyoak, GBartels, Kenneth E.Bunting, Charles F.Slobodov, GennadyKrasinki, Jerzy S.2023-07-072023-07-072008-10-15Jiang, Z., Piao, D., ... Krasinki, J.S. (2008). Trans-rectal ultrasound-coupled near-infrared optical tomography of the prostate. Part II: Experimental demonstration. Optics Express, 16(22), 17505-17520. https://doi.org/10.1364/OE.16.0175051094-4087https://hdl.handle.net/20.500.14446/337917We demonstrate trans-rectal optical tomography of the prostate using an endo-rectal near-infrared (NIR) applicator integrated with a transrectal ultrasound (TRUS) probe. The endo-rectal NIR applicator incorporated a design presented in our previously reported work. A continuous-wave NIR optical tomography system is combined with a commercial US scanner to form the dual-modality imager. Sagittal transrectal imaging is performed concurrently by endo-rectal NIR and TRUS. The TRUS ensures accurate positioning of the NIR applicator as well as guides NIR image reconstruction using the spatial prior of the target. The use of a condom, which is standard for TRUS, is found to have minimal effect on trans-rectal NIR imaging. Tests on avian tissues validates that NIR imaging can recover the absorption contrast of a target, and its accuracy is improved when the TRUS spatial prior is incorporated. Trans-rectal NIR/US imaging of a healthy canine prostate in situ is reported.application/pdfThis material has been previously published. In the Oklahoma State University Library's institutional repository this version is made available through the open access principles and the terms of agreement/consent between the author(s) and the publisher. The permission policy on the use, reproduction or distribution of the material falls under fair use for educational, scholarship, and research purposes. Contact Digital Resources and Discovery Services at lib-dls@okstate.edu or 405-744-9161 for further information.2023-07-0310.1364/OE.16.017505Articleatomic, molecular and optical physicsphysical sciencesbioengineeringprostate cancerpreventioncancerurologic diseasesbiomedical imagingoptical physicselectrical and electronic engineeringcommunications technologiesopticscommunications engineeringelectronics, sensors and digital hardwareanimalscalibrationchickensdogsinfrared raysmalephantoms, imagingprostaterectumtomography, opticalultrasonographyScopusID: 57199784187 (Jiang, Z)ORCID: 0000-0003-0922-6885 (Piao, D)ScopusID: 7005153312 | 57220465193 (Piao, D)ResearcherID: I-1341-2013 (Piao, D)ScopusID: 55510777100 (Xu, G)ORCID: 0000-0003-0307-4673 (Ritchey, JW)ScopusID: 7006378376 (Ritchey, JW)ScopusID: 6701722645 (Reed Holyoak, G)ScopusID: 7005400149 (Bartels, KE)ORCID: 0000-0001-9167-4235 (Bunting, CF)ScopusID: 7004209277 (Bunting, CF)ScopusID: 8984047600 (Slobodov, G)ScopusID: 56036164800 (Krasinki, JS)1094-4087