Piao, DaqingSadeghi, Mehran M.Zhang, JiashengChen, YueliSinusas, AJZhu, Quing2023-07-072023-07-072005-07-01Piao, D., Sadeghi, M.M., Zhang, J., Chen, Y., Sinusas, A.J., Zhu, Q. (2005). Hybrid positron detection and optical coherence tomography system: Design, calibration, and experimental validation with rabbit atherosclerotic models. Journal of Biomedical Optics, 10(4), 044010-1-044010-10. https://doi.org/10.1117/1.19547731083-3668https://hdl.handle.net/20.500.14446/337916We evaluate the performance of our novel hybrid optical coherence tomography (OCT) and scintillating probe, demonstrate simultaneous OCT imaging and scintillating detection, and validate the system using an atherosclerotic rabbit model. Preliminary data obtained from the rabbit model suggest that our prototype positron probe detects local uptake of fluorodeoxyglucose (FDG) labeled with F positron (beta) radionuclide emitter, and the high-uptake regions correlate with sites of injury and extensive atherosclerosis areas. Preliminary data also suggest that coregistered high-resolution OCT images provide imaging of detailed plaque microstructures, which cannot be resolved by positron detection.application/pdfThis material has been previously published. In the Oklahoma State University Library's institutional repository this version is made available through the open access principles and the terms of agreement/consent between the author(s) and the publisher. The permission policy on the use, reproduction or distribution of the material falls under fair use for educational, scholarship, and research purposes. Contact Digital Resources and Discovery Services at lib-dls@okstate.edu or 405-744-9161 for further information.2023-07-0310.1117/1.1954773Articlefluid mechanics and thermal engineeringbiomedical and clinical sciencesengineeringbiomedical imagingagingbioengineeringcardiovascularatherosclerosisevaluation of markers and technologiesdetection, screening and diagnosisoptical physicsopticsophthalmology and optometryatomic, molecular and optical physicsanimalscalibrationcatheters, indwellingdisease models, animalequipment designequipment failure analysisfluorodeoxyglucose f18image enhancementpositron-emission tomographyrabbitsradionuclide imagingradiopharmaceuticalssubtraction techniquesystems integrationtomography, optical coherencetransducersORCID: 0000-0003-0922-6885 (Piao, D)ScopusID: 7005153312 | 57220465193 (Piao, D)ResearcherID: I-1341-2013 (Piao, D)ScopusID: 35599478400 (Sadeghi, MM)ScopusID: 55720125300 (Zhang, J)ScopusID: 8380855900 (Chen, Y)ScopusID: 7006837185 (Sinusas, AJ)ScopusID: 7403313690 (Zhu, Q)1560-2281