Apblett, Allen W.Asmamaw, Tsedenia Tsegaye2014-03-142014-03-142011-07-01http://hdl.handle.net/20.500.14446/8074Altretamine (hexamethylmelamine) is a chemotherapeutic agent used to treat advanced ovarian cancer. A simple one-pot synthesis procedure has been developed for the synthesis of altretamine under mild reaction condition. The preparation of atretamine has been performed by cyclotrimerization of dimethylcyanamide using tungsten and molybdenum hydrogen bronze as catalyst. These hydrogen bronzes are simply products obtained from hydrogen insertion into tungsten and molybdenum trioxides. The reaction was carried out in sealed culture tube at 150C and the products were characterized by using nuclear magnetic resonance (NMR), gas chromatography/mass spectrometric analysis (GC-MS) and, infrared spectroscopy (IR). The same reaction can be applied to methylthiocyanate.application/pdfCopyright is held by the author who has granted the Oklahoma State University Library the non-exclusive right to share this material in its institutional repository. Contact Digital Library Services at lib-dls@okstate.edu or 405-744-9161 for the permission policy on the use, reproduction or distribution of this material.textaltretaminecyclotrimerizationdimethylcyanamidemethylthiocyanates-trazine