This research analyzes the relationship between global determinants of health and mortality from the H1N1 2009 pandemic. Grounded in social vulnerability and social determinants of paradigms, six variables were examined in relationship with H1N1 2009 mortality. These are; health, education, communication, population, air transport, and governance variables of 193 WHO member states. Health had three indicators (Health Expenditure per capita, International Health Regulations and Health Emergency Preparedness, and Adult mortality), Education had two (Education expenditure, and adult literacy, ), Communication three (Radio, and Television penetration, and cell phone subscription), Population had two (population living in urban areas and international migrant stock), a single indicator of air transport, and two indicators of governance (Corruption Perception Index and Human Development Index). I conducted a multiple regression analysis to examine the relationship between these indicators and H1N1 2009 mortality. Results indicated significant relationship between the indicators and H1N12009 mortality. In addition, for each of the group of indicators, regression identified statistically significant predictors of H1N12009 mortality. The findings suggest that social vulnerability and social determinants of health provide a robust conceptual framework by which to examine pandemic disaster mortality.