By 2030, 1 in 6 people in the world will be aged 60 years or older, increasing the importance of interventional therapies for age-associated diseases. Research investigating cultural dietary differences recognized that the use of herbal medicine supplementation such as processed Panax ginseng, referred to as red ginseng (RG), increases lifespan in Asian countries by facilitating healthy aging. However, the mechanism for how RG prevents, delays, or reverses aging-related diseases is unknown. Thus, this study assessed how RG facilitates healthy aging by identifying cellular and molecular mechanisms of hepatic senescence pathways in an aged mouse model.