Introduction: It is well known that increases in strength following resistance training are due to neural and muscle hypertrophy adaptations. However, it is unknown if divergent focused resistance training results in differing adaptations in motor unit behavior to modulate submaximal force when muscle hypertrophy occurs or is attenuated. Additionally, little is known if divergent resistance training can influence motor unit behavior during an absolute muscular endurance task to failure. Methods: Two distinct experiments were conducted to expand on the literature regarding the influence of divergent resistance training on maximal strength, motor unit behavior, muscle hypertrophy, and absolute muscular endurance. The first study investigated the effects of 6 weeks of combined high- and low-load resistance training to high-load only training on maximal strength, muscle hypertrophy, and motor unit recruitment and firing rate patterns during a moderate- and high-intensity muscle actions. The second study examined the influence of divergent training from study one on absolute muscular endurance and motor unit behavior of the vastus lateralis during repetitive muscle actions at task failure. Conclusion: For project one, six weeks of divergent focused resistance-training resulted in similar increases in maximal strength, but different relative change in muscle hypertrophy and motor unit recruitment and firing rate patterns of the vastus lateralis to modulate submaximal moderate- and high-intensity torques. For project two, absolute muscular endurance improved for the combined high- and low-load training group only; however, similar MU recruitment and firing rate patterns were observed for both groups following training. Therefore, neither short-term training intervention altered motor control strategies at task failure.